Journal of Cachexia, Sarcopenia and Muscle (JCSM) Abstract
Article first published online: 7 DEC 2017
miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting
SMartin Connolly, Richard Paul, Roser Farre-Garros, Samantha A. Natanek, Susannah Bloch, Jen Lee, Jose P. Lorenzo, Harnish Patel, Cyrus Cooper, Avan A. Sayer, Stephen J. Wort, Mark Griffiths, Michael I. Polkey, Paul R. Kemp
A major component of the cancer anorexia-cachexia syndrome is a decline in food intake. Up until now none of the drugs that improve appetite also improve skeletal muscle. Recent studies have suggested that the oral ghrelin-analog, anamorelin, increased food intake and muscle mass. Unfortunately, it does not increase muscle power. Its regulatory future is uncertain, although it has important clinical effects.
Connolly, M., Paul, R., Farre-Garros, R., Natanek, S. A., Bloch, S., Lee, J., Lorenzo, J. P., Patel, H., Cooper, C., Sayer, A. A., Wort, S. J., Griffiths, M., Polkey, M. I., and Kemp, P. R. (2017) miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting. Journal of Cachexia, Sarcopenia and Muscle, doi: 10.1002/jcsm.12266.