Journal of Cachexia, Sarcopenia and Muscle (JCSM) - Abstract

Volume 5, Number 4, Page 278 - 285

Cachexia: a problem of energetic inefficiency

Josep M. Argilés, Cibely Cristine Fontes-Oliveira, Miriam Toledo, Francisco J. López-Soriano, Sílvia Busquets

An alteration of energy balance is the immediate cause of the so-called cachexia. Although alterations of energy intake are often associated with cachexia, it has lately became clear that an increased energy expenditure is the main cause of wasting associated with different types of pathological conditions, such as cancer, infections or chronic heart failure among others. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss; among them, adenosine triphosphate (ATP) consumption by sarcoplasmic reticulum Ca2+ pumps could represent a key mechanism. In other cases, an increase in energy inefficiency will further contribute to energy imbalance.

Argilés J.M., Fontes-Oliveira C.C., Toledo M., López-Soriano F.J., Busquets S., Cachexia: a problem of energetic inefficiency. J Cachex Sarcopenia Muscle 2014;4:278-285.